Essential
ICSI ®
Complete & Affordable ICSI
Essential ICSI by Manchester Fertility offers patients low-cost ICSI treatment for £3900. It includes everything you will need for a single ICSI cycle to give you the best chance of success.
Our affordable ICSI package includes the very best patient support. Our expert nurse-led team will provide compassion and support throughout your treatment with us.


Last Updated: 5th June 2024
Clinically Reviewed on 05/06/24 4:03p.m. by Dr Raj Mathur MD, FRCOG
What is ICSI?
Intracytoplasmic sperm injection, or ICSI, is a fertilisation technique used in IVF. It involves injecting a single healthy sperm into each mature egg to maximise the chance of fertilisation in couples where there is a male fertility problem.
As the sperm directly fertilises the eggs, issues with sperm motility (movement), sperm morphology (shape), or number (low sperm count) can be overcome, giving men with sperm problems the chance to become fathers.
ICSI may also be recommended for:
- Patients who have had failed fertilisation or very low fertilisation in previous treatments
- Some cases of frozen sperm where the number of motile sperm are low
- Surgically retrieved sperm
- Cases where eggs have been frozen
What is different about Essential ICSI?
ICSI is the most common treatment for male fertility issues. The technique is the same for patients as a standard ICSI treatment, where the sperm is injected directly into the egg. The only difference is that it is a lower-cost treatment compared to standard ICSI as the consultations and treatment planning stages are nurse-led.
Senior Consultant Raj Mathur will oversee Essential ICSI procedures. Experienced fertility doctors and consultants will carry out egg collections and embryo transfers.

Who is Essential ICSI for?
Essential ICSI is available for patients who need our help getting pregnant and who meet our eligibility criteria.
- Heterosexual couples
- Single females
- Same-sex female couples

Am I eligible for Essential ICSI?
In order to proceed with Essential ICSI, we ask patients to meet our criteria, which are set to ensure the best possible success rate for you. The key indicators for treatment are age, BMI and ovarian reserve.
Check if you're eligible
Yes, let's get startedNot sure if you're eligible?
Don't worry, contact us to discuss your options.
Call us today 0345 646 1778
Certain medical issues identified, including any anomalies identified on a scan, could mean that you are not able to proceed with Essential IVF/ICSI. However, if this is the case, don't worry; our fertility experts will explain all the options available to you and recommend the best treatment pathway for you.
Essential ICSI Package
£3900
We believe we have the most comprehensive low-cost IVF with ICSI treatment package. Our all-inclusive package costs £3900 and includes everything you will need to maximise your chance of success
*If patient has surplus embryos includes freezing and storage for one year
Inclusive Treatment Package
- All Medication
- Freezing and Storage (1st Year)
- One Frozen Embryo Transfer
- Donor Sperm Available (Extra Cost)
- Time-Lapse Imaging
- Online Consent Platform
- Patient Support App
- Electronic Witnessing
- Cycle Planning
- Injection Teaching
- Monitoring Blood Tests
- Monitoring Scans
- Sedation for Egg Collection
- Ultrasound-Guided Egg Collection
- Sperm Preparation/Insemination of Eggs by ICSI
- EmbryoGlue
- Embro Culture up to Blastocyst Stage
- Embryo Transfer/Embryo Freezing
- HFEA License Fee
- Pregnancy Scan
- Follow Up Consultation
- Counselling (Optional)
Donor Sperm
If you need donor sperm for Essential Fertility, we can provide a comprehensive selection of identifiable and screened UK sperm donors from our own donor sperm bank, Semovo. Having our own donor sperm bank means sperm is readily available and we are able to provide all parts of your treatment within one clinic.
During your treatment, you are supported by our caring and experienced team, from choosing your sperm donor to your pregnancy test.
- UK donors of multiple ethnicities
- No waiting list
- Detailed donor profiles
- Licensed and registered with the HFEA

ICSI Treatment Process
1Check Eligibility Criteria
Before we can begin your Essential ICSI journey, you will need to check your eligibility via our website or by calling our New Patient Coordinator team. If you need tests to see if you meet our eligibility criteria, your New Patient Coordinator will arrange these. Female tests include an AMH blood test and pelvic ultrasound, and for a male, this includes a semen analysis.
2Consultation with a Senior Fertility Nurse
Our senior fertility nurses will take a full medical history and discuss the results of your tests and plan your ICSI cycle for the best chance of success.
3Ovarian Stimulation
The first stage of ICSI is ovarian stimulation. This involves using tailored doses of fertility drugs to help produce mature eggs.
4Egg Maturation
A ‘trigger’ injection of fertility medications is administered to assist with the final maturation of eggs and loosening of the eggs from the follicle walls.
5Egg Collection
Egg collection takes place in our clinic theatre under ultrasound guidance. Before the egg collection, we provide you with a sedative. The eggs are retrieved from the follicles where they have been growing.
6Injection of sperm into mature eggs
The sperm sample is washed and prepared. Our expert embryology team identify and select the best healthy sperm from your sample. We look for active sperm that are moving well and are shaped normally. Each mature egg is then injected with an individual sperm under the microscope. The injected eggs are placed into the time-lapse imaging incubators to monitor for fertilisation.
7Fertilisation
We monitor your eggs for signs of fertilisation. This usually occurs 16-18 hours after insemination.
8Embryo Culture
The created embryos are placed in an incubator where they grow in the lab for the next two to five days. Our embryologists keep you updated on the process of your embryos and advise when your embryo transfer will take place.
9Embryo Transfer
Our embryologists will select an embryo, which is transferred under ultrasound guidance into your uterus by our fertility consultants. Embryo replacement will take place in our specially-designed transfer room.
10Vitrification
Any remaining good quality embryos that are not transferred are frozen and stored. Frozen embryos can be used in subsequent cycles if the first cycle is not successful or for sibling pregnancy.
11Pregnancy Test
You can take a home pregnancy test around two weeks after your embryo transfer. During this time, you will be supported by our clinic midwife. If your test is positive, you will be booked in for your early pregnancy scan about three weeks later.
Risks
As a HFEA-regulated clinic, Manchester Fertility has a duty to highlight any potential risks to patients undergoing fertility treatment. Although fertility treatment such as the ones we provide via Essential Fertility are normally safe, there are some risks to be aware of, such as:
- Ovarian hyperstimulation syndrome: When ovaries overreact to the fertility drugs needed to produce mature eggs.
- Damage to eggs: There are a small number of eggs that are damaged during the ICSI procedure (<5%)
- Genetic or developmental defects: There have been reports that children born using the ICSI technique are at a slightly higher risk to have genetic problems or developmental defects. There isn’t conclusive evidence that this is related to the technique but may be linked to the underlying infertility.
- Multiple pregnancy or birth (twins, triplets or more): If more than one embryo is transferred, there is an increased chance of a multiple pregnancy.
- Ectopic pregnancy: There is a possibility that during embryo transfer, it could travel to the fallopian tube instead.
Patients should consider these risks, and they will be discussed at your consultation. However, in our experience, most patients who decide to proceed with treatment have no (or few) problems with their health or pregnancy.

